Pralidoxime and amoxapine both decrease cholinergic effects/transmission.
Pralidoxime and amitriptyline both decrease cholinergic effects/transmission. Pralidoxime and aclidinium both decrease cholinergic effects/transmission.
Administer in the anterolateral aspect of the thigh to avoid the nerve, artery and vein, as well as the femurĮither increases effects of the other by pharmacodynamic synergism. #ATROPINE ANTIDOTE SERIES#
If symptoms persist may repeat series of three injections 1 hr after last injection. 40 kg or greater: 600 mg IM x3 doses administer each dose 15 minutes apart for mild symptoms, or in rapid succession for severe symptoms not to exceed 1800 mg total dose initially. Alternatively, administer 30 mg/kg IV (IM, SC if no IV access) over 20 min follow by 4-8 mg/kg/hr maintenance IV infusion. 1-2 g IV infusion (10-20 mg/mL) over 15-30 min, repeat in 1 hr if necessary and repeat q12hr thereafter PRN if not practical or if pulmonary edema present or fluid restriction necessary administer as 50 mg/mL over 5 min a second bolus of 1-2 g may be indicated after about 1 hr if muscle weakness has not been relieved may repeat q10-12hr prn. Reduce dose no specific recommendations provided by manufacturer IM: 600 mg IM x3 doses administer each dose 15 minutes apart for mild symptoms, or in rapid succession for severe symptoms not to exceed 1800 mg total dose initially if symptoms persist may repeat series of three injections 1 hr after last injection Acetylcholinesterase Inhibitor Toxicity (Neostigmine, Pyridostigmine)ġ-2 g IV followed by 250 mg increments q5min PRN Renal Impairment Use with atropine, which affects muscarinic receptors pralidoxime's actions most striking at nicotonic sites (increase muscle strength 10-40 min) Dosage Forms & Strengths powder for reconstitutionġ-2 g IV infusion (10-20 mg/mL) over 15-30 min, repeat in 1 hr if necessary and repeat q12hr thereafter PRN if not practical or if pulmonary edema present or fluid restriction necessary administer as 50 mg/mL over 5 min a second bolus of 1-2 g may be indicated after about 1 hr if muscle weakness has not been relieved may repeat q10-12hr prnĪlternatively, administer 30 mg/kg IV (IM, SC if no IV access) over 20 min follow by 4-8 mg/kg/hr maintenance IV infusion
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